Syphilis

Syphilis moves through four stages, and the first sign is usually a single painless sore that heals on its own whether or not you are treated. It is curable at any stage, but the damage it does is not undone.

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Why test for syphilis?

The first sore is painlessBecause it does not hurt, the CDC notes you may never notice it.
It heals on its ownThe sore clears in 3 to 6 weeks with or without treatment - the infection does not.
The rash can reach palms and solesThe second stage often starts with a rash, sometimes on the palms of the hands or the bottoms of the feet.
It passes to babies in pregnancyCongenital syphilis is what happens when it is passed on during pregnancy.

When can I test?

Syphilis does not show up immediately after exposure.

1If you have a sore, get seen nowDo not wait. A sore can be tested directly, and syphilis is easiest to treat early. A blood test can take up to 12 weeks after exposure to turn positive, so a negative before then does not rule it out.
2Give a blood sampleA single draw at a local lab. The visit itself takes about 15 minutes.
3Results in 1-2 daysIf positive, treatment is prescribed by a provider and partners should be tested too.

What Is Syphilis?

Syphilis is a sexually transmitted infection that develops in stages — primary, secondary, latent and tertiary — and each stage has different signs and symptoms. Without treatment it can cause serious health problems. Babies can also get syphilis: congenital syphilis is what happens when it passes from a woman to her baby during pregnancy.

Syphilis symptoms

Syphilis moves through four stages. The primary stage brings a single sore — sometimes several — at the spot the infection entered, typically about three weeks after exposure though it can be anywhere from 10 to 90 days. The sore is usually painless and often goes unnoticed when it is inside the mouth, vagina or rectum. It lasts three to six weeks and heals on its own whether or not you are treated, which is why it is so easily missed. The secondary stage usually begins about four to ten weeks after the first sore appears, most often as a rash on the trunk, palms and soles, sometimes with sores in the mouth, vagina or anus, fever and swollen glands. That resolves by itself too. The latent stage has no signs at all and can last years. Most people with untreated syphilis never reach the tertiary stage, but a substantial minority do — published estimates range from about a quarter to a third — typically 10 to 30 years on, when the infection damages the heart and blood vessels, the brain and the nervous system. Syphilis can also affect the eyes, ears and nervous system at any stage. Because every early sign disappears without treatment, the absence of a sore or rash tells you nothing — only a blood test does.

How is syphilis spread?

Syphilis spreads through direct contact with a syphilis sore during vaginal, anal or oral sex. The sores occur in, on or around the penis, vagina, anus, rectum, lips or mouth. Because the first sore is usually painless, you may never notice it — and it heals on its own whether or not you are treated, which is why the infection so often goes unrecognised.

How is syphilis treated?

Syphilis is curable at any stage with antibiotics prescribed by a healthcare provider. Treatment stops the infection progressing, but it does not reverse damage already done, which is why catching it early matters. Avoid sex until treatment is complete and any sores have healed, and make sure partners are tested and treated too.

How common is syphilis?

Reported primary & secondary syphilis cases in the United States, 2000–2023

53,007reported cases, 20238.7×change since 2000
20002023
2023: 53,007 reported cases nationally, a rate of 15.8 per 100,000 — primary and secondary stages only; down 10.2% from 2022, the first major drop in over two decades.
Primary and secondary stages only — not all stages. 2023 is the CDC published national total.
Highest rates by state
SD84 per 100k
767 cases
NM36 per 100k
761 cases
AR33 per 100k
1,001 cases
OK32 per 100k
1,278 cases
MS31 per 100k
913 cases
Sources
Last reviewed August 2026. This page is informational and is not medical advice. Where a figure cannot be sourced it is not stated.

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