STD Testing in Sioux Falls, SD
10 places to get tested — 4 partner labs that need no appointment, and 6 clinics and testing sites in and near Sioux Falls.
- 4partner labs
- 1free clinic
- 5sliding scale
Order a test online
Pick a panel, visit a lab nearby, results in 1–2 days. No appointment, no insurance.
GET TESTED NOWCompare pricing →4,500+ labs nationwide · from $24Partner labs near Sioux Falls
Order online, then walk in the same day with no appointment. A urine or blood sample takes about 15 minutes, and results come back in 1–2 days. They are confidential: never reported to your insurance company or added to your medical record.
Sanford Laboratories
0.8 mi awayNo appointment$10 off orders over $100 applied at checkoutOrder a test for this lab →Sanford Laboratories
0.9 mi awayNo appointmentOpen Saturday$10 off orders over $100 applied at checkoutOrder a test for this lab →Sanford Laboratories
1.0 mi awayNo appointment$10 off orders over $100 applied at checkoutOrder a test for this lab →Sanford Laboratories
2.3 mi awayNo appointment$10 off orders over $100 applied at checkoutOrder a test for this lab →
We earn a commission if you order through the links above. It does not change what you pay, and it does not decide which labs are listed — those are the closest partner labs to Sioux Falls.
Explore testing locations in and near Sioux Falls
Clinics and testing sites in and near Sioux Falls
6 clinics are listed below, closest first — including 1 that lists free testing and 5 that list sliding-scale fees. Public clinics generally take longer to return results than a private lab, and several test on set days only, so it is worth calling ahead. If you would rather not wait or give your details at a public clinic, the 4 partner labs in Sioux Falls need no appointment and return results in 1–2 days.
How we chose these 6 clinics
- Every one is on the CDC’s GetTested locatorThe wider CDC directory we draw from has over 16,000 entries. Only the ones GetTested also lists can appear here, and all 6 clinics below do.
- Listings that name fewer than three tests are left outEven on GetTested, 527 listings name fewer than three tests. We don’t show them anywhere.
- Unverified pregnancy centers are never shownThe CDC lists some pregnancy centers whose STD testing we couldn’t verify. We don’t list them anywhere.
- Cost is stated the way the CDC lists itFree, sliding scale or insurance accepted, as each clinic reports it to the CDC. We don’t estimate prices, and if the listing says nothing, the card says “Fees not listed.”
Directory retrieved September 4, 2026. Open “View services” on any card to see when that clinic last updated its listing. All sources
- Public health department3.9 mi away
South Dakota Department of Health
Sioux Falls HIV/AIDS and STD Testing Field Office
1501 S Highline Ave, Sioux Falls, SD, 57106
HoursNot listedAppointmentsAppointment requiredFeesFree STI testing listed- HIV & STI testing
- Treats STIs
- Interpretation listed
CallWebsiteDirectionsView services
Tests Chlamydia · Gonorrhea · Syphilis · HIV · Hepatitis B · Hepatitis C · Hepatitis A · TB
Treatments STI treatment · HPV vaccine · Hep B vaccine · Free condoms · PrEP navigation · Case management
Languages English · interpreter available
CDC GetTested listing, last updated by the source February 10, 2026. Directory retrieved September 4, 2026.
Buy an at-home STD test near Sioux Falls and online
Walgreens, Walmart, CVS Pharmacy and Target sell over-the-counter test kits near Sioux Falls, and myLAB Box ships one to your door. You collect the sample at home and mail it to a lab. Stock varies by branch — call ahead or check online before making the trip.
Walgreens
Nearest branch · 1.1 mi6 storesWalmart
Nearest branch · 2.9 mi3 storesCVS Pharmacy
Nearest branch · 2.9 mi2 storesTarget
Nearest branch · 3.0 mi2 storesmyLAB Box
Online · ships nationwideMail-in kit
We earn a commission if you order a myLAB Box kit through the link above. It does not change what you pay, and it does not decide which pharmacies are listed — those are the chains with branches near Sioux Falls.
Minnehaha County STD rates
Reported cases per 100,000 residents. Change shown against the year before.
Chlamydia
▼ 5%698.8per 100k
1,446 reported cases · 2023 · 31% above the SD rate
Gonorrhea
▼ 10.3%365.3per 100k
756 reported cases · 2023 · 44% above the SD rate
Syphilis
▼ 24.2%56.5per 100k
117 reported cases · 2023 · 23% below the SD rate
HIV
▲ 57.1%22new diagnoses
2023 · rate not published
Source: CDC NCHHSTP AtlasPlus, 2023 release · Minnehaha County SD STD Statistics
There were 22 new HIV diagnoses in Minnehaha County in 2023. HIV is the one infection where how soon you test changes which test you need — an RNA test detects it far earlier than a standard antibody test.
Minnehaha County reported 1,446 chlamydia cases in 2023, a rate of 698.8 per 100,000 residents. That is above the national average, which is why routine testing matters here more than it does in most of the country — and most people who have chlamydia or gonorrhea have no symptoms at all, so waiting for something to feel wrong is not a strategy.
HIV prevention & treatment
PrEP, DoxyPEP & Online Treatment
A test result is the start, not the end. If you are negative and want to stay that way, PrEP and DoxyPEP cut the risk of a future infection. If you are positive, most STIs can be treated without setting foot in a clinic. Both are available to people in Sioux Falls by video visit, prescribed by clinicians licensed in South Dakota.
- Treatment & DoxyPEP
Wisp
STI treatment $39 · DoxyPEP from $22
Treatment for an STI, and DoxyPEP, prescribed online. The prescription goes to your pharmacy the same day.
Visit Wisp - HIV PrEP & DoxyPEP
Q Care Plus
$0 for most insured patients
PrEP and DoxyPEP by video visit, with test kits posted to you and follow-up bloodwork tracked between refills.
Visit Q Care Plus - HIV PrEP & DoxyPEP
MISTR
$0 with or without insurance
HIV prevention handled entirely from home: PrEP and the lab work that goes with it, no appointment.
Visit MISTR
Prices depend on your insurance and change frequently — check the provider’s own site before ordering. None of these replace emergency care.
STD testing in Sioux Falls, answered
Where can I find free or sliding-scale STD testing in Sioux Falls?
Among the 6 clinics listed in Sioux Falls, 1 lists free testing for at least one infection and 5 list sliding-scale fees. Confirm eligibility and charges before visiting. Free testing is listed at South Dakota Department of Health.
How much does STD testing cost in Sioux Falls?
Among the 6 clinics listed in Sioux Falls, 1 list free testing for at least one infection and 5 charge on a sliding scale based on income. Private lab testing is a flat price paid up front — no insurance is filed, so nothing appears on an explanation of benefits.
Can I get tested on a weekend in Sioux Falls?
None of the 6 listed clinics publish weekend hours, so testing here means a weekday visit. An at-home collection kit is the alternative if weekdays are difficult.
How common are STDs in Sioux Falls?
In 2023, Minnehaha County reported 1,446 chlamydia cases — a rate of 698.8 per 100,000 residents. Gonorrhea was 365.3 per 100,000. There were also 22 new HIV diagnoses in 2023.
Is testing available in Spanish in Sioux Falls?
1 of the 6 listed clinics indicate that Spanish-language services are available, and 4 list PrEP.
- Partner labs
- Quest and Labcorp location directories · checked August 2026
- Public clinics
- CDC GetTested / NPIN directory · retrieved September 4, 2026
- Retailers
- Retailer store directories · updated September 2026
- Statistics
- CDC NCHHSTP AtlasPlus · reporting year 2023
- HIV diagnoses
- CDC HIV Surveillance · reporting year 2023
