STD Rates in St. Louis City, Missouri

2023 CDC surveillance data for St. Louis City, Missouri — chlamydia, gonorrhea, and syphilis rates with state comparisons.

Data Year: 2023 Source: CDC STI Surveillance Population: 281,751
Combined
2201.6
per 100K
1st / 115
Chlamydia
1340.9
per 100K • 3,778 cases
US rate: 490.7
1st of 115 in Missouri
Higher than 98% of US counties
Gonorrhea
809.9
per 100K • 2,282 cases
US rate: 178.2
1st of 115 in Missouri
Higher than 99% of US counties
Syphilis P&S
50.8
per 100K • 143 cases
US rate: 15.8
5th of 115 in Missouri
Higher than 96% of US counties

St. Louis City has one of the higher STD burdens in Missouri, with a combined rate of 2,201.6 per 100,000 residents in 2023 — ranking 1st of 115 counties. Reported infections included chlamydia at 1340.9 per 100,000 (3,778 cases, 169% above the state rate), gonorrhea at 809.9 per 100,000 (2,282 cases, 301% above the state rate), syphilis at 50.8 per 100,000 (143 cases, 136% above the state rate). Many STDs show no symptoms, so testing is the only reliable way to know your status. Confidential options are available across St. Louis City.

STD Trends in St. Louis City, 2000–2023

Reported cases per 100,000 residents each year, against the Missouri rate (dashed). In a county this size a handful of cases moves the rate a long way, so read the shape rather than any single year.

Chlamydia
1,340.9
per 100K in 2023
781.4 in 2000
Peak 1,453.6 in 2011
Gonorrhea
809.9
per 100K in 2023
829.8 in 2000
Peak 909.2 in 2001
Syphilis (P&S)
50.8
per 100K in 2023
3.2 in 2000
Peak 65.3 in 2022

Source: CDC NCHHSTP AtlasPlus county surveillance, 2000–2023.

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St. Louis City vs Missouri and the US

Infection St. Louis City Missouri US vs Missouri vs US Rank in Missouri
Chlamydia 1340.93,778 cases 498.6 490.7 168.9% above 173.3% above 1st of 115
Gonorrhea 809.92,282 cases 201.9 178.2 301.1% above 354.5% above 1st of 115
Syphilis (P&S) 50.8143 cases 21.5 15.8 136.3% above 221.5% above 5th of 115

Rates per 100,000 residents, 2023. Ranks run from the highest rate (1st) among Missouri’s counties. The US rate is all 50 states combined. Comparisons are left out where fewer than 20 cases were reported, because a rate built on so few cases can swing widely from one year to the next.

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FAQs

St. Louis City ranks 1st of 115 Missouri counties for combined STD rate in 2023, at 2,201.6 per 100,000 residents.
In 2023, chlamydia was the most frequently reported STD in St. Louis City, with 3,778 cases at a rate of 1340.9 per 100,000 residents.
STDTest.com lists confidential testing locations across St. Louis City and Missouri. Many offer same-day appointments with results in 1–3 days.
Data sourced from the CDC's annual STI Surveillance Report. Rates are per 100,000 population and reflect reported cases only — actual prevalence is likely higher due to undiagnosed infections. While we strive for accuracy, STDTest.com makes no representations or warranties regarding the completeness or accuracy of this data and is not responsible for any errors or omissions. This page is for informational purposes only and does not constitute medical advice.