STD Rates in Greenville County, South Carolina

2023 CDC surveillance data for Greenville County, South Carolina — chlamydia, gonorrhea, and syphilis rates with state comparisons.

Data Year: 2023 Source: CDC STI Surveillance Population: 558,078
Combined
729.6
per 100K
30th / 46
Chlamydia
528.6
per 100K • 2,950 cases
US rate: 490.7
29th of 46 in South Carolina
Higher than 80% of US counties
Gonorrhea
185.8
per 100K • 1,037 cases
US rate: 178.2
30th of 46 in South Carolina
Higher than 82% of US counties
Syphilis P&S
15.2
per 100K • 85 cases
US rate: 15.8
26th of 46 in South Carolina
Higher than 73% of US counties

Greenville County recorded a combined STD rate of 729.6 per 100,000 residents in 2023, ranking 30th of 46 counties in South Carolina. Reported infections included chlamydia at 528.6 per 100,000 (2,950 cases, 14% below the state rate), gonorrhea at 185.8 per 100,000 (1,037 cases, 16% below the state rate), syphilis at 15.2 per 100,000 (85 cases, 12% below the state rate). Confidential STD testing is available throughout Greenville County — knowing your status is the only way to catch infections that often show no symptoms.

STD Trends in Greenville County, 2000–2023

Reported cases per 100,000 residents each year, against the South Carolina rate (dashed). In a county this size a handful of cases moves the rate a long way, so read the shape rather than any single year.

Chlamydia
528.6
per 100K in 2023
72.2 in 2000
Peak 644.0 in 2021
Gonorrhea
185.8
per 100K in 2023
84.5 in 2000
Peak 316.8 in 2020
Syphilis (P&S)
15.2
per 100K in 2023
3.4 in 2000
Peak 23.0 in 2021

Source: CDC NCHHSTP AtlasPlus county surveillance, 2000–2023.

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Greenville County vs South Carolina and the US

Infection Greenville County South Carolina US vs South Carolina vs US Rank in South Carolina
Chlamydia 528.62,950 cases 612.1 490.7 13.6% below 7.7% above 29th of 46
Gonorrhea 185.81,037 cases 222.4 178.2 16.5% below 4.3% above 30th of 46
Syphilis (P&S) 15.285 cases 17.3 15.8 12.1% below 3.8% below 26th of 46

Rates per 100,000 residents, 2023. Ranks run from the highest rate (1st) among South Carolina’s counties. The US rate is all 50 states combined. Comparisons are left out where fewer than 20 cases were reported, because a rate built on so few cases can swing widely from one year to the next.

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FAQs

Greenville County ranks 30th of 46 South Carolina counties for combined STD rate in 2023, at 729.6 per 100,000 residents.
In 2023, chlamydia was the most frequently reported STD in Greenville County, with 2,950 cases at a rate of 528.6 per 100,000 residents.
STDTest.com lists confidential testing locations across Greenville County and South Carolina. Many offer same-day appointments with results in 1–3 days.
Data sourced from the CDC's annual STI Surveillance Report. Rates are per 100,000 population and reflect reported cases only — actual prevalence is likely higher due to undiagnosed infections. While we strive for accuracy, STDTest.com makes no representations or warranties regarding the completeness or accuracy of this data and is not responsible for any errors or omissions. This page is for informational purposes only and does not constitute medical advice.