At-Home Testing

At-Home Syphilis Test: How It Works & Where to Order

Test for syphilis from home with a finger-prick blood spot kit — no clinic visit, no appointment. Lab-certified results delivered to your secure account in approximately 5 days.

Finger-prick blood spot

CLIA & CAP certified labs

Results in approx. 5 days

Free physician consult if positive

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Included in

Panels that include this test:

✓ Uber Box — 8 panel ✓ Total Box — 14 panel

Uber Box — Best Value

Syphilis + HIV, chlamydia, gonorrhea, herpes, hep C, trich

$199

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Free shipping · Discreet packaging · FSA/HSA accepted

What Is an At-Home Syphilis Test?

An at-home syphilis test detects antibodies to Treponema pallidum — the bacterium that causes syphilis — using a finger-prick blood spot sample you collect at home. You order online, receive the kit in discreet packaging, prick your finger to collect a few drops of blood on the provided card, and mail it to a CLIA-certified lab. Results are posted to your secure online account in approximately 5 days.

Syphilis is included in the Uber Box (8 panel) and the Total Box (14 panel) — but not in the Safe Box (5 panel). If syphilis screening is a priority, the Uber Box is the most cost-effective option.

If you test positive, a physician from the provider’s network will contact you by phone to discuss results and arrange confirmatory testing. Syphilis is curable with antibiotics — early detection is important because untreated syphilis progresses through stages and can cause serious long-term complications.

How At-Home Syphilis Test Works

Four steps from order to results — no clinic required.

Order Your Kit

Choose the Uber Box or Total Box — both include syphilis screening. Your kit ships in plain, unmarked packaging.

Collect Your Sample

Use the included lancet to prick your fingertip and collect a few drops of blood on the dried blood spot card. Takes about 5 minutes.

Mail It Back

Drop your sample in the prepaid return envelope and leave it for your mail carrier or drop it at any USPS location.

Get Your Results

Results are posted to your secure account in approximately 5 days. You’ll get a notification when they’re ready.

How Accurate Is At-Home Syphilis Test?

>85%

Sensitivity (Treponemal antibody test)

Treponemal antibody tests have a sensitivity exceeding 85% across all stages of syphilis. Sensitivity is higher in primary and secondary syphilis than in late-stage infection.

>99%

Specificity

False positives can occur in some conditions. A positive result may be confirmed with a second test before a diagnosis is made.

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When Should You Test After Exposure?

Syphilis has a window period of 3–6 weeks after exposure. Testing too soon may produce a false negative. If you had a potential exposure within the past 6 weeks and test negative, retest after 6 weeks to confirm.

See the full STD testing window period guide →

Which Kit Should You Order?

⭐ Best Value myLAB Box — Uber Box — 8 Panel

Uber Box

Comprehensive screening including syphilis — in one kit.

✓ Syphilis
✓ HIV I & II
✓ Chlamydia
✓ Gonorrhea
✓ Herpes Simplex 2
✓ Hepatitis C
✓ Trichomoniasis

Other Options

Safe Box — 5 Panel

Does not include syphilis · $169

Total Box — 14 Panel

Adds throat & rectal screening, MG, HPV · $369–$399

Order Now → Compare All Panels

Free shipping · FSA/HSA accepted · Discreet packaging

Frequently Asked Questions

Yes. At-home syphilis tests use a finger-prick blood spot sample you collect at home and mail to a certified lab. The lab tests for treponemal antibodies and posts results to your secure account in approximately 5 days. No clinic visit or appointment required.

Syphilis has a window period of 3–6 weeks. Testing too soon may produce a false negative. If you had a potential exposure within the past 6 weeks and test negative, retest after 6 weeks to confirm. See our full guide to STD testing window periods.

No — syphilis is not included in the Safe Box (5 panel). It is included in the Uber Box (8 panel) and Total Box (14 panel). If syphilis screening is a priority, the Uber Box is the most cost-effective option.

Syphilis progresses through stages. Primary syphilis typically causes a painless sore (chancre) at the site of infection. Secondary syphilis can cause a rash, flu-like symptoms, and sores. Many people have no symptoms at all, which is why testing is important even without obvious signs.

A physician from the provider’s network will contact you by phone to discuss results and prescribe treatment. Syphilis is curable with antibiotics — penicillin is the standard treatment. Early detection is important because untreated syphilis can cause serious complications over time.

No. At-home kits ordered from myLAB Box are not billed through insurance and won’t appear on your explanation of benefits. Results are stored in a HIPAA-compliant portal and are not shared with insurers.